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Q00493

Carboxypeptidase E (Q00493)

Uniprot ID Q00493
Protein Name Carboxypeptidase E
Gene Name Cpe
Species Mus musculus (Mouse)
Basic Information Experiments (7) Disease (5) Interactions
Signal peptide(a) Y Secretome P(b) 0.426
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
GO - Molecular function
  • carboxypeptidase activity : IMP:MGI
  • cell adhesion molecule binding : ISO:MGI
  • cobalt ion binding : ISO:MGI
  • metallocarboxypeptidase activity : ISO:MGI
  • neurexin family protein binding : ISO:MGI
  • peptidase activity : TAS:Reactome
  • protein domain specific binding : ISO:MGI
  • serine-type carboxypeptidase activity : IBA:GO_Central
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cardiac left ventricle morphogenesis : ISO:MGI
  • enkephalin processing : ISO:MGI
  • insulin processing : IMP:MGI
  • negative regulation of branching morphogenesis of a nerve : ISO:MGI
  • peptide catabolic process : ISO:MGI
  • peptide metabolic process : ISO:MGI
  • protein localization to membrane : ISO:MGI
  • protein processing : ISO:MGI
  • Wnt signaling pathway : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.