| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). . |
| GO - Molecular function |
- integrin binding : IMP:RGD
- protein-containing complex binding : IPI:RGD
|
| GO - Biological process |
- acute inflammatory response to antigenic stimulus : IMP:RGD
- adhesion of symbiont to host : ISO:RGD
- cell adhesion : ISO:RGD
- cell adhesion mediated by integrin : ISO:RGD
- cell aging : IEP:RGD
- cell-cell adhesion : IDA:RGD
- cellular response to alkaloid : IEP:RGD
- cellular response to amyloid-beta : ISO:RGD
- cellular response to dexamethasone stimulus : IEP:RGD
- cellular response to glucose stimulus : IEP:RGD
- cellular response to hypoxia : IEP:RGD
- cellular response to interferon-gamma : IEP:RGD
- cellular response to interleukin-1 : IEP:RGD
- cellular response to interleukin-6 : IEP:RGD
- cellular response to leukemia inhibitory factor : ISO:RGD
- cellular response to lipopolysaccharide : IEP:RGD
- cellular response to nutrient levels : IEP:RGD
- cellular response to organic substance : IEP:RGD
- cellular response to tumor necrosis factor : IEP:RGD
- establishment of endothelial barrier : ISO:RGD
- establishment of endothelial intestinal barrier : IMP:RGD
- establishment of Sertoli cell barrier : IDA:RGD
- leukocyte cell-cell adhesion : ISO:RGD
- leukocyte migration : ISO:RGD
- membrane to membrane docking : ISO:RGD
- negative regulation of calcium ion transport : IDA:RGD
- negative regulation of endothelial cell apoptotic process : ISO:RGD
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD
- ovarian follicle development : IEP:RGD
- positive regulation of actin filament polymerization : IDA:RGD
- positive regulation of cellular extravasation : ISO:RGD
- positive regulation of ERK1 and ERK2 cascade : ISO:RGD
- positive regulation of GTPase activity : IDA:RGD
- positive regulation of leukocyte adhesion to vascular endothelial cell : IMP:RGD
- positive regulation of NF-kappaB transcription factor activity : IMP:RGD
- positive regulation of nitric oxide biosynthetic process : IMP:RGD
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:RGD
- positive regulation of vasoconstriction : IMP:RGD
- receptor-mediated virion attachment to host cell : ISO:RGD
- regulation of cell shape : IMP:RGD
- regulation of ruffle assembly : ISO:RGD
- response to amino acid : IEP:RGD
- response to amphetamine : IEP:RGD
- response to copper ion : IEP:RGD
- response to drug : IEP:RGD
- response to ethanol : IEP:RGD
- response to gonadotropin : IEP:RGD
- response to hypoxia : IEP:RGD
- response to insulin : IEP:RGD
- response to ionizing radiation : IEP:RGD
- response to lipopolysaccharide : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- response to sulfur dioxide : IEP:RGD
- sensory perception of sound : IMP:RGD
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : ISO:RGD
- T cell antigen processing and presentation : ISO:RGD
- T cell extravasation : ISO:RGD
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