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P98156

Very low-density lipoprotein receptor (P98156)

Uniprot ID P98156
Protein Name Very low-density lipoprotein receptor
Gene Name Vldlr
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (4) Interactions
Signal peptide(a) Y Secretome P(b) 0.421
Function Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
GO - Molecular function
  • apolipoprotein binding : ISO:MGI
  • calcium ion binding : IEA:InterPro
  • calcium-dependent protein binding : ISO:MGI
  • glycoprotein transporter activity : ISO:MGI
  • reelin receptor activity : IMP:CACAO
  • very-low-density lipoprotein particle binding : ISO:MGI
  • very-low-density lipoprotein particle receptor activity : ISS:BHF-UCL
GO - Biological process
  • cellular response to hypoxia : ISO:MGI
  • cholesterol metabolic process : IEA:UniProtKB-KW
  • dendrite morphogenesis : IMP:CACAO
  • glycoprotein transport : ISO:MGI
  • lipid transport : IEA:UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II : IMP:BHF-UCL
  • positive regulation of dendrite development : IGI:BHF-UCL
  • positive regulation of protein kinase activity : IGI:MGI
  • receptor-mediated endocytosis : ISO:MGI
  • reelin-mediated signaling pathway : IGI:BHF-UCL
  • ventral spinal cord development : IEP:UniProtKB
  • very-low-density lipoprotein particle clearance : ISS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.