Very low-density lipoprotein receptor (P98155)

Uniprot ID P98155
Protein Name Very low-density lipoprotein receptor
Gene Name VLDLR
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.483
Function Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). .
GO - Molecular function
  • apolipoprotein binding : IDA:BHF-UCL
  • calcium ion binding : IEA:InterPro
  • calcium-dependent protein binding : IPI:BHF-UCL
  • cargo receptor activity : IDA:BHF-UCL
  • low-density lipoprotein particle receptor activity : TAS:ProtInc
  • reelin receptor activity : ISS:BHF-UCL
  • very-low-density lipoprotein particle binding : IDA:BHF-UCL
  • very-low-density lipoprotein particle receptor activity : IDA:BHF-UCL
GO - Biological process
  • axon guidance : TAS:Reactome
  • cholesterol metabolic process : IEA:UniProtKB-KW
  • dendrite morphogenesis : IEA:Ensembl
  • glycoprotein transport : IDA:BHF-UCL
  • lipid transport : IEA:UniProtKB-KW
  • low-density lipoprotein particle receptor catabolic process : TAS:Reactome
  • memory : TAS:ProtInc
  • nervous system development : TAS:ProtInc
  • positive regulation of dendrite development : ISS:BHF-UCL
  • positive regulation of protein kinase activity : IEA:Ensembl
  • receptor-mediated endocytosis : IDA:BHF-UCL
  • reelin-mediated signaling pathway : ISS:BHF-UCL
  • signal transduction : TAS:ProtInc
  • ventral spinal cord development : IEA:Ensembl
  • very-low-density lipoprotein particle clearance : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.