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P97447

Four and a half LIM domains protein 1 (P97447)

Uniprot ID P97447
Protein Name Four and a half LIM domains protein 1
Gene Name Fhl1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.539
Function May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.
GO - Molecular function
  • ion channel binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cell differentiation : IEA:UniProtKB-KW
  • multicellular organism development : IEA:UniProtKB-KW
  • negative regulation of cell growth : ISO:MGI
  • negative regulation of G1/S transition of mitotic cell cycle : ISO:MGI
  • negative regulation of G2/M transition of mitotic cell cycle : ISO:MGI
  • positive regulation of potassium ion transport : ISO:MGI
  • regulation of membrane depolarization : ISO:MGI
  • regulation of potassium ion transmembrane transporter activity : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.