T-complex protein 1 subunit gamma (P80318)

Uniprot ID P80318
Protein Name T-complex protein 1 subunit gamma
Gene Name Cct3
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.643
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Plays a role in the assembly of the von Hippel-Lindau ubiquitination complex (By similarity). Interacts with DNAAF4. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • protein binding involved in protein folding : IBA:GO_Central
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • 'de novo' protein folding : IBA:GO_Central
  • binding of sperm to zona pellucida : IDA:MGI
  • chaperone-mediated protein folding : IBA:GO_Central
  • pore complex assembly : IMP:MGI
  • positive regulation of establishment of protein localization to telomere : ISO:MGI
  • positive regulation of telomere maintenance via telomerase : ISO:MGI
  • protein stabilization : ISO:MGI
  • toxin transport : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.