Bleomycin hydrolase (P70645)

Uniprot ID P70645
Protein Name Bleomycin hydrolase
Gene Name Blmh
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics. .
GO - Molecular function
  • cysteine-type endopeptidase activity : IEA:InterPro
  • cysteine-type peptidase activity : IBA:GO_Central
  • identical protein binding : ISO:RGD
  • peptidase activity : ISO:RGD
GO - Biological process
  • homocysteine catabolic process : IBA:GO_Central
  • response to drug : ISO:RGD
  • response to toxic substance : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.