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P70580

Membrane-associated progesterone receptor component 1 (P70580)

Uniprot ID P70580
Protein Name Membrane-associated progesterone receptor component 1
Gene Name Pgrmc1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b)
Function Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity (PubMed:9006096). .
GO - Molecular function
  • heme binding : ISS:UniProtKB
  • protein homodimerization activity : ISS:UniProtKB
  • steroid binding : IEA:UniProtKB-KW
GO - Biological process
  • associative learning : IGI:ARUK-UCL
  • axon guidance : IEP:RGD
  • heme biosynthetic process : ISS:UniProtKB
  • memory : IGI:ARUK-UCL
  • modification of synaptic structure : IGI:ARUK-UCL
  • negative regulation of synapse organization : IGI:ARUK-UCL
  • positive regulation of protein localization to plasma membrane : IMP:ARUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.