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P70490

Lactadherin (P70490)

Uniprot ID P70490
Protein Name Lactadherin
Gene Name Mfge8
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b)
Function Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid. .
GO - Molecular function
  • integrin binding : ISO:RGD
  • phosphatidylethanolamine binding : ISO:RGD
  • phosphatidylserine binding : ISO:RGD
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • apoptotic cell clearance : ISO:RGD
  • cell adhesion : IEA:UniProtKB-KW
  • phagocytosis, engulfment : ISO:RGD
  • phagocytosis, recognition : ISO:RGD
  • positive regulation of cell population proliferation : IEP:RGD
  • positive regulation of phagocytosis : ISO:RGD
  • response to estrogen : IEP:RGD
  • single fertilization : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.