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P70296

Phosphatidylethanolamine-binding protein 1 (P70296)

Uniprot ID P70296
Protein Name Phosphatidylethanolamine-binding protein 1
Gene Name Pebp1
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (4) Interactions
Signal peptide(a) N Secretome P(b) 0.81
Function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). .HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
GO - Molecular function
  • ATP binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • kinase binding : ISO:MGI
  • lipid binding : IEA:UniProtKB-KW
  • mitogen-activated protein kinase binding : ISO:MGI
  • protein kinase binding : ISO:MGI
  • receptor serine/threonine kinase binding : IEA:Ensembl
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
  • signaling receptor binding : ISO:MGI
GO - Biological process
  • aging : IEA:Ensembl
  • eating behavior : IEA:Ensembl
  • hippocampus development : IEA:Ensembl
  • MAPK cascade : ISO:MGI
  • negative regulation of MAPK cascade : ISO:MGI
  • negative regulation of protein phosphorylation : ISO:MGI
  • positive regulation of acetylcholine metabolic process : ISO:MGI
  • positive regulation of cAMP-mediated signaling : ISO:MGI
  • positive regulation of mitotic nuclear division : ISO:MGI
  • regulation of neurotransmitter levels : ISO:MGI
  • regulation of the force of heart contraction : ISO:MGI
  • response to activity : IEA:Ensembl
  • response to calcium ion : IEA:Ensembl
  • response to cAMP : IEA:Ensembl
  • response to corticosterone : IEA:Ensembl
  • response to electrical stimulus : IEA:Ensembl
  • response to ethanol : IEA:Ensembl
  • response to heat : IEA:Ensembl
  • response to oxidative stress : IEA:Ensembl
  • response to wounding : IEA:Ensembl
  • sperm capacitation : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.