14-3-3 protein eta (P68510)

Uniprot ID P68510
Protein Name 14-3-3 protein eta
Gene Name Ywhah
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.455
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). .
GO - Molecular function
  • actin binding : IDA:ProtInc
  • enzyme binding : ISO:MGI
  • glucocorticoid receptor binding : ISS:UniProtKB
  • identical protein binding : ISO:MGI
  • ion channel binding : IPI:BHF-UCL
  • protein domain specific binding : IDA:MGI
  • protein heterodimerization activity : ISO:MGI
  • sodium channel regulator activity : ISS:BHF-UCL
GO - Biological process
  • cytoskeleton organization : NAS:ProtInc
  • glucocorticoid catabolic process : ISS:UniProtKB
  • glucocorticoid receptor signaling pathway : ISS:UniProtKB
  • intracellular protein transport : IDA:MGI
  • membrane depolarization during action potential : ISS:BHF-UCL
  • negative regulation of apoptotic process : NAS:ProtInc
  • negative regulation of dendrite morphogenesis : IDA:MGI
  • positive regulation of transcription, DNA-templated : ISS:UniProtKB
  • regulation of mitotic nuclear division : NAS:ProtInc
  • regulation of sodium ion transmembrane transporter activity : ISS:BHF-UCL
  • regulation of sodium ion transport : ISS:BHF-UCL
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.