Receptor of activated protein C kinase 1 (P68040)

Uniprot ID P68040
Protein Name Receptor of activated protein C kinase 1
Gene Name Rack1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.62
Function Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity). .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • cyclin binding : ISO:MGI
  • cysteine-type endopeptidase activator activity involved in apoptotic process : ISO:MGI
  • enzyme binding : ISO:MGI
  • ion channel inhibitor activity : IDA:UniProtKB
  • protein homodimerization activity : ISO:MGI
  • protein kinase C binding : ISS:UniProtKB
  • protein phosphatase binding : ISO:MGI
  • protein tyrosine kinase inhibitor activity : ISS:UniProtKB
  • receptor tyrosine kinase binding : ISS:UniProtKB
  • ribosome binding : ISS:UniProtKB
  • SH2 domain binding : ISS:UniProtKB
  • signaling adaptor activity : ISO:MGI
  • signaling receptor activity : ISO:MGI
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
  • cell cycle : IEA:UniProtKB-KW
  • cellular response to glucose stimulus : ISO:MGI
  • cellular response to growth factor stimulus : ISS:UniProtKB
  • gastrulation : IEA:UniProtKB-KW
  • intracellular signal transduction : ISO:MGI
  • negative regulation of cell growth : ISS:UniProtKB
  • negative regulation of gene expression : ISO:MGI
  • negative regulation of hydrogen peroxide-induced neuron death : IGI:ParkinsonsUK-UCL
  • negative regulation of peptidyl-serine phosphorylation : ISO:MGI
  • negative regulation of phagocytosis : ISS:UniProtKB
  • negative regulation of protein kinase B signaling : ISO:MGI
  • negative regulation of translation : ISO:MGI
  • negative regulation of Wnt signaling pathway : ISS:UniProtKB
  • pigmentation : IMP:MGI
  • positive regulation of apoptotic process : ISS:UniProtKB
  • positive regulation of cAMP catabolic process : ISO:MGI
  • positive regulation of cell migration : ISS:UniProtKB
  • positive regulation of cyclic-nucleotide phosphodiesterase activity : ISO:MGI
  • positive regulation of gastrulation : ISS:UniProtKB
  • positive regulation of Golgi to plasma membrane protein transport : ISS:UniProtKB
  • positive regulation of GTPase activity : ISS:UniProtKB
  • positive regulation of intrinsic apoptotic signaling pathway : ISO:MGI
  • positive regulation of mitochondrial depolarization : ISO:MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process : ISS:UniProtKB
  • positive regulation of protein homooligomerization : ISS:UniProtKB
  • positive regulation of protein phosphorylation : ISS:UniProtKB
  • protein localization : ISO:MGI
  • protein ubiquitination : ISS:UniProtKB
  • regulation of cell cycle : ISS:UniProtKB
  • regulation of cell division : ISS:UniProtKB
  • regulation of establishment of cell polarity : ISS:UniProtKB
  • regulation of protein localization : ISS:UniProtKB
  • regulation of protein localization to plasma membrane : ISO:MGI
  • rescue of stalled ribosome : ISS:UniProtKB
  • rhythmic process : IEA:UniProtKB-KW
  • translation : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.