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P67775

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (P67775 )

Uniprot ID P67775
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Name PPP2CA
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. .
GO - Molecular function
  • GABA receptor binding : IEA:Ensembl
  • metal ion binding : IEA:UniProtKB-KW
  • phosphoprotein phosphatase activity : TAS:ARUK-UCL
  • protein C-terminus binding : IEA:Ensembl
  • protein heterodimerization activity : IPI:UniProtKB
  • protein serine/threonine phosphatase activity : IDA:UniProtKB
  • tau protein binding : NAS:ARUK-UCL
GO - Biological process
  • apoptotic process : TAS:UniProtKB
  • ceramide metabolic process : NAS:UniProtKB
  • inactivation of MAPK activity : NAS:UniProtKB
  • meiotic cell cycle : IEA:UniProtKB-KW
  • mesoderm development : IEA:Ensembl
  • mitotic nuclear envelope reassembly : TAS:Reactome
  • negative regulation of cell growth : NAS:UniProtKB
  • negative regulation of epithelial to mesenchymal transition : IMP:BHF-UCL
  • negative regulation of tyrosine phosphorylation of STAT protein : NAS:UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay : TAS:Reactome
  • peptidyl-serine dephosphorylation : TAS:ARUK-UCL
  • peptidyl-threonine dephosphorylation : IDA:UniProtKB
  • positive regulation of microtubule binding : ISS:ARUK-UCL
  • positive regulation of protein serine/threonine kinase activity : IMP:BHF-UCL
  • protein dephosphorylation : TAS:UniProtKB
  • regulation of cell adhesion : NAS:UniProtKB
  • regulation of cell differentiation : NAS:UniProtKB
  • regulation of DNA replication : NAS:UniProtKB
  • regulation of growth : NAS:UniProtKB
  • regulation of microtubule binding : NAS:ARUK-UCL
  • regulation of protein phosphorylation : NAS:ARUK-UCL
  • regulation of transcription, DNA-templated : NAS:UniProtKB
  • regulation of Wnt signaling pathway : NAS:UniProtKB
  • response to lead ion : ISS:ARUK-UCL
  • response to organic substance : NAS:UniProtKB
  • RNA splicing : NAS:UniProtKB
  • second-messenger-mediated signaling : NAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.