14-3-3 protein zeta/delta (P63102)

Uniprot ID P63102
Protein Name 14-3-3 protein zeta/delta
Gene Name Ywhaz
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (PubMed:16959763). .
GO - Molecular function
  • identical protein binding : ISO:RGD
  • ion channel binding : ISO:RGD
  • protein domain specific binding : ISS:UniProtKB
  • protein kinase binding : ISO:RGD
  • protein-containing complex binding : IPI:RGD
  • transcription factor binding : ISO:RGD
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • establishment of Golgi localization : ISO:RGD
  • Golgi reassembly : ISO:RGD
  • histamine secretion by mast cell : IMP:RGD
  • protein phosphorylation : ISS:UniProtKB
  • protein targeting : ISO:RGD
  • protein targeting to mitochondrion : IDA:RGD
  • regulation of cell death : ISO:RGD
  • regulation of ERK1 and ERK2 cascade : ISS:UniProtKB
  • regulation of synapse maturation : ISO:RGD
  • response to drug : IDA:RGD
  • signal transduction : ISS:UniProtKB
  • synaptic target recognition : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.