Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (P63087)

Uniprot ID P63087
Protein Name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Gene Name Ppp1cc
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.717
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. .Isoform 2: Required for normal male fertility. {ECO:0000269|PubMed:23082183}.
GO - Molecular function
  • lamin binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • phosphatase activity : IDA:UniProtKB
  • protein C-terminus binding : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein kinase binding : IEA:Ensembl
  • protein N-terminus binding : ISO:MGI
  • protein phosphatase 1 binding : ISO:MGI
  • protein phosphatase binding : ISO:MGI
  • protein serine/threonine phosphatase activity : IDA:MGI
  • protein-containing complex binding : ISO:MGI
GO - Biological process
  • cell cycle : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • circadian regulation of gene expression : IDA:UniProtKB
  • entrainment of circadian clock by photoperiod : IMP:UniProtKB
  • glycogen metabolic process : IEA:UniProtKB-KW
  • neuron differentiation : ISS:MGI
  • positive regulation of glial cell proliferation : IEA:Ensembl
  • protein dephosphorylation : IDA:UniProtKB
  • regulation of circadian rhythm : IDA:UniProtKB
  • regulation of nucleocytoplasmic transport : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.