V-type proton ATPase 16 kDa proteolipid subunit (P63082)

Uniprot ID P63082
Protein Name V-type proton ATPase 16 kDa proteolipid subunit
Gene Name Atp6v0c
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.235
Function Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
GO - Molecular function
  • proton-exporting ATPase activity, phosphorylative mechanism : ISA:MGI
  • proton-transporting ATPase activity, rotational mechanism : IBA:GO_Central
  • ubiquitin protein ligase binding : ISO:MGI
GO - Biological process
  • ATP hydrolysis coupled proton transport : IEA:InterPro
  • lysosomal lumen acidification : TAS:MGI
  • positive regulation of Wnt signaling pathway : ISO:MGI
  • vacuolar acidification : TAS:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.