60 kDa heat shock protein, mitochondrial (P63038)

Uniprot ID P63038
Protein Name 60 kDa heat shock protein, mitochondrial
Gene Name Hspd1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.384
Function Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. .
GO - Molecular function
  • apolipoprotein A-I binding : ISO:MGI
  • apolipoprotein binding : ISO:MGI
  • ATP binding : IEA:UniProtKB-KW
  • chaperone binding : ISO:MGI
  • double-stranded RNA binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • high-density lipoprotein particle binding : ISO:MGI
  • hydrolase activity : IEA:UniProtKB-KW
  • insulin binding : ISO:MGI
  • lipopolysaccharide binding : IDA:BHF-UCL
  • modification-dependent protein binding : ISO:MGI
  • p53 binding : ISO:MGI
  • protease binding : ISO:MGI
  • protein binding involved in protein folding : IBA:GO_Central
  • protein heterodimerization activity : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • ubiquitin protein ligase binding : ISO:MGI
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • 'de novo' protein folding : IBA:GO_Central
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
  • apoptotic mitochondrial changes : ISO:MGI
  • B cell activation : ISO:MGI
  • B cell cytokine production : ISO:MGI
  • B cell proliferation : ISO:MGI
  • cellular response to heat : IEA:Ensembl
  • chaperone-mediated protein folding : IBA:GO_Central
  • interaction with symbiont : ISO:MGI
  • isotype switching to IgG isotypes : ISO:MGI
  • MyD88-dependent toll-like receptor signaling pathway : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of apoptotic process in bone marrow : ISO:MGI
  • negative regulation of neuron apoptotic process : ISO:MGI
  • negative regulation of reactive oxygen species biosynthetic process : ISO:MGI
  • positive regulation of apoptotic process : ISO:MGI
  • positive regulation of inflammatory response : ISO:MGI
  • positive regulation of interferon-alpha production : IDA:MGI
  • positive regulation of interferon-gamma production : IDA:BHF-UCL
  • positive regulation of interleukin-10 production : ISO:MGI
  • positive regulation of interleukin-12 production : ISO:MGI
  • positive regulation of interleukin-6 production : ISO:MGI
  • positive regulation of interleukin-6 secretion : ISO:MGI
  • positive regulation of macrophage activation : ISO:MGI
  • positive regulation of T cell activation : IDA:BHF-UCL
  • positive regulation of T cell mediated immune response to tumor cell : ISO:MGI
  • positive regulation of tumor necrosis factor secretion : ISO:MGI
  • protein import into mitochondrial intermembrane space : IBA:GO_Central
  • protein refolding : ISO:MGI
  • protein stabilization : ISO:MGI
  • response to activity : IEA:Ensembl
  • response to ATP : IEA:Ensembl
  • response to cocaine : IEA:Ensembl
  • response to cold : ISS:AgBase
  • response to estrogen : IEA:Ensembl
  • response to glucocorticoid : IEA:Ensembl
  • response to hydrogen peroxide : IEA:Ensembl
  • response to hypoxia : IEA:Ensembl
  • response to ischemia : IEA:Ensembl
  • response to lipopolysaccharide : IEA:Ensembl
  • response to unfolded protein : ISO:MGI
  • T cell activation : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.