| Signal peptide(a) |
N |
Secretome P(b) |
0.85 |
| Function |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). . |
| GO - Molecular function |
- actin binding : ISO:MGI
- actin monomer binding : ISO:MGI
- adenyl-nucleotide exchange factor activity : ISO:MGI
- cadherin binding : ISO:MGI
- phosphatidylinositol-4,5-bisphosphate binding : ISO:MGI
- proline-rich region binding : ISO:MGI
- Rho GTPase binding : IPI:BHF-UCL
- signaling receptor binding : ISO:MGI
|
| GO - Biological process |
- actin cytoskeleton organization : IEA:InterPro
- cellular response to growth factor stimulus : IEA:Ensembl
- negative regulation of actin filament bundle assembly : ISO:MGI
- negative regulation of actin filament polymerization : ISO:MGI
- negative regulation of stress fiber assembly : ISO:MGI
- neural tube closure : IGI:MGI
- positive regulation of actin filament bundle assembly : IBA:GO_Central
- positive regulation of actin filament polymerization : ISO:MGI
- positive regulation of ATPase activity : ISO:MGI
- positive regulation of DNA metabolic process : ISO:MGI
- positive regulation of epithelial cell migration : ISO:MGI
- positive regulation of ruffle assembly : ISO:MGI
- positive regulation of stress fiber assembly : ISO:MGI
- positive regulation of transcription by RNA polymerase II : ISO:MGI
- positive regulation of viral transcription : ISO:MGI
- protein stabilization : ISO:MGI
- regulation of actin polymerization or depolymerization : TAS:MGI
- regulation of transcription by RNA polymerase II : IGI:MGI
- sequestering of actin monomers : TAS:MGI
|