40S ribosomal protein S3 (P62908)

Uniprot ID P62908
Protein Name 40S ribosomal protein S3
Gene Name Rps3
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.731
Function Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). Stimulates the N-glycosylase activity of the base excision protein OGG1 (By similarity). Enhances the uracil excision activity of UNG1 (By similarity). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (By similarity). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (By similarity). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (By similarity). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (By similarity). Represses its own translation by binding to its cognate mRNA (By similarity). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (By similarity). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (By similarity). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (By similarity). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (By similarity). .
GO - Molecular function
  • class I DNA-(apurinic or apyrimidinic site) endonuclease activity : IEA:UniProtKB-EC
  • damaged DNA binding : ISO:MGI
  • DNA binding : ISO:MGI
  • DNA-(apurinic or apyrimidinic site) endonuclease activity : IDA:UniProtKB
  • endodeoxyribonuclease activity : ISO:MGI
  • enzyme binding : ISO:MGI
  • Hsp70 protein binding : ISO:MGI
  • Hsp90 protein binding : ISO:MGI
  • kinase binding : ISO:MGI
  • microtubule binding : ISO:MGI
  • mRNA binding : ISO:MGI
  • oxidized purine DNA binding : ISO:MGI
  • oxidized purine nucleobase lesion DNA N-glycosylase activity : IBA:GO_Central
  • oxidized pyrimidine DNA binding : ISO:MGI
  • protein kinase A binding : ISO:MGI
  • protein kinase binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • RNA binding : ISO:MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding : IEA:Ensembl
  • small ribosomal subunit rRNA binding : ISO:MGI
  • structural constituent of ribosome : IBA:GO_Central
  • supercoiled DNA binding : ISO:MGI
  • transcription factor binding : ISO:MGI
  • tubulin binding : ISO:MGI
  • ubiquitin-like protein conjugating enzyme binding : ISO:MGI
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • cellular response to DNA damage stimulus : ISO:MGI
  • cellular response to hydrogen peroxide : ISO:MGI
  • cellular response to nerve growth factor stimulus : ISO:MGI
  • cellular response to tumor necrosis factor : ISO:MGI
  • chromosome segregation : ISO:MGI
  • cytoplasmic translation : IBA:GO_Central
  • DNA damage response, detection of DNA damage : ISO:MGI
  • DNA repair : IBA:GO_Central
  • negative regulation of DNA repair : ISO:MGI
  • negative regulation of protein ubiquitination : ISO:MGI
  • negative regulation of translation : ISO:MGI
  • positive regulation of activated T cell proliferation : ISO:MGI
  • positive regulation of apoptotic signaling pathway : ISO:MGI
  • positive regulation of base-excision repair : ISO:MGI
  • positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis : ISO:MGI
  • positive regulation of DNA N-glycosylase activity : ISO:MGI
  • positive regulation of DNA repair : ISO:MGI
  • positive regulation of endodeoxyribonuclease activity : ISO:MGI
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of interleukin-2 production : ISO:MGI
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage : ISO:MGI
  • positive regulation of JUN kinase activity : ISO:MGI
  • positive regulation of microtubule polymerization : ISO:MGI
  • positive regulation of NF-kappaB transcription factor activity : IMP:CAFA
  • positive regulation of NIK/NF-kappaB signaling : ISO:MGI
  • positive regulation of protein complex assembly : IMP:CAFA
  • positive regulation of T cell receptor signaling pathway : ISO:MGI
  • regulation of apoptotic process : ISO:MGI
  • response to oxidative stress : ISO:MGI
  • response to TNF agonist : ISO:MGI
  • spindle assembly : ISO:MGI
  • transcription, DNA-templated : IEA:UniProtKB-KW
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.