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P60843

Eukaryotic initiation factor 4A-I (P60843)

Uniprot ID P60843
Protein Name Eukaryotic initiation factor 4A-I
Gene Name Eif4a1
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.788
Function ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATP-dependent RNA helicase activity : IBA:GO_Central
  • double-stranded RNA binding : ISO:MGI
  • translation initiation factor activity : IEA:UniProtKB-KW
GO - Biological process
  • regulation of gene expression : IBA:GO_Central
  • RNA secondary structure unwinding : IBA:GO_Central
  • translational initiation : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.