RuvB-like 1 (P60122)

Uniprot ID P60122
Protein Name RuvB-like 1
Gene Name Ruvbl1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.553
Function Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. .Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity). {ECO:0000250}.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250}.Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation (By similarity). {ECO:0000250}.May be able to bind plasminogen at cell surface and enhance plasminogen activation. {ECO:0000250}.
GO - Molecular function
  • ADP binding : IDA:UniProtKB
  • ATP binding : IDA:UniProtKB
  • ATP-dependent 3'-5' DNA helicase activity : ISO:MGI
  • ATP-dependent 5'-3' DNA helicase activity : IEA:InterPro
  • ATP-dependent DNA helicase activity : IBA:GO_Central
  • ATPase activity : ISO:MGI
  • ATPase binding : IPI:UniProtKB
  • DNA helicase activity : ISO:MGI
  • TBP-class protein binding : ISO:MGI
  • TFIID-class transcription factor binding : IPI:UniProtKB
  • transcription coactivator activity : ISO:MGI
GO - Biological process
  • box C/D snoRNP assembly : IBA:GO_Central
  • cell cycle : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • chromatin remodeling : IBA:GO_Central
  • DNA recombination : IEA:UniProtKB-KW
  • DNA repair : IEA:UniProtKB-KW
  • histone acetylation : IBA:GO_Central
  • histone H2A acetylation : ISS:UniProtKB
  • histone H4 acetylation : ISS:UniProtKB
  • positive regulation of canonical Wnt signaling pathway : ISO:MGI
  • positive regulation of plasminogen activation : ISO:MGI
  • regulation of fibroblast apoptotic process : ISO:MGI
  • regulation of growth : IEA:UniProtKB-KW
  • regulation of transcription by RNA polymerase II : IBA:GO_Central
  • transcription, DNA-templated : IEA:UniProtKB-KW
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.