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P57780

Alpha-actinin-4 (P57780)

Uniprot ID P57780
Protein Name Alpha-actinin-4
Gene Name Actn4
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.513
Function F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (PubMed:18332111). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (By similarity). .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
  • calcium ion binding : IEA:InterPro
  • chromatin DNA binding : ISO:MGI
  • ion channel binding : ISO:MGI
  • ligand-dependent nuclear receptor transcription coactivator activity : ISS:UniProtKB
  • nuclear hormone receptor binding : ISO:MGI
  • nucleoside binding : ISO:MGI
  • protein homodimerization activity : ISO:MGI
  • protein N-terminus binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • retinoic acid receptor binding : ISO:MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • actin filament bundle assembly : IDA:UniProtKB
  • bicellular tight junction assembly : IMP:UniProtKB
  • negative regulation of cellular component movement : IDA:UniProtKB
  • negative regulation of substrate adhesion-dependent cell spreading : ISO:MGI
  • peroxisome proliferator activated receptor signaling pathway : ISS:UniProtKB
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cellular component movement : IDA:UniProtKB
  • positive regulation of NIK/NF-kappaB signaling : ISO:MGI
  • positive regulation of pinocytosis : IMP:UniProtKB
  • protein localization to bicellular tight junction : IMP:UniProtKB
  • protein transport : IEA:UniProtKB-KW
  • regulation of apoptotic process : ISO:MGI
  • regulation of nucleic acid-templated transcription : ISO:MGI
  • response to hypoxia : IEA:Ensembl
  • retinoic acid receptor signaling pathway : ISS:UniProtKB
  • vesicle transport along actin filament : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.