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P56212

cAMP-regulated phosphoprotein 19 (P56212)

Uniprot ID P56212
Protein Name cAMP-regulated phosphoprotein 19
Gene Name Arpp19
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.891
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). .
GO - Molecular function
  • phosphatase inhibitor activity : ISS:UniProtKB
  • potassium channel regulator activity : ISO:MGI
  • protein phosphatase 2A binding : ISS:UniProtKB
  • protein phosphatase inhibitor activity : IBA:GO_Central
  • protein phosphatase regulator activity : ISS:UniProtKB
  • signaling receptor binding : ISO:MGI
GO - Biological process
  • cell division : IEA:UniProtKB-KW
  • G2/M transition of mitotic cell cycle : ISS:UniProtKB
  • mitotic cell cycle : ISS:UniProtKB
  • negative regulation of protein dephosphorylation : IBA:GO_Central
  • positive regulation of gluconeogenesis : ISO:MGI
  • positive regulation of Ras protein signal transduction : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.