Phospholipid transfer protein (P55065)

Uniprot ID P55065
Protein Name Phospholipid transfer protein
Gene Name Pltp
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.646
Function Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity). .
GO - Molecular function
  • ceramide binding : ISO:MGI
  • ceramide transporter activity : ISO:MGI
  • diacylglycerol binding : ISO:MGI
  • lipid transporter activity : ISO:MGI
  • phosphatidic acid binding : ISO:MGI
  • phosphatidic acid transporter activity : ISO:MGI
  • phosphatidylcholine binding : ISO:MGI
  • phosphatidylcholine transporter activity : ISO:MGI
  • phosphatidylethanolamine binding : ISO:MGI
  • phosphatidylethanolamine transporter activity : ISO:MGI
  • phosphatidylglycerol binding : ISO:MGI
  • phospholipid transporter activity : ISO:MGI
GO - Biological process
  • ceramide transport : ISO:MGI
  • flagellated sperm motility : IMP:MGI
  • high-density lipoprotein particle remodeling : ISO:MGI
  • lipid metabolic process : IEA:InterPro
  • lipid transport : ISO:MGI
  • phospholipid transport : ISO:MGI
  • positive regulation of cholesterol efflux : ISO:MGI
  • vitamin E biosynthetic process : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.