Apolipoprotein D (P51910)

Uniprot ID P51910
Protein Name Apolipoprotein D
Gene Name Apod
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.709
Function APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
GO - Molecular function
  • cholesterol binding : ISS:UniProtKB
GO - Biological process
  • aging : ISS:UniProtKB
  • brain development : ISS:UniProtKB
  • glucose metabolic process : ISS:UniProtKB
  • lipid metabolic process : ISS:UniProtKB
  • lipid transport : IEA:InterPro
  • negative regulation of cytokine production involved in inflammatory response : ISS:UniProtKB
  • negative regulation of focal adhesion assembly : ISS:UniProtKB
  • negative regulation of lipoprotein lipid oxidation : IMP:UniProtKB
  • negative regulation of monocyte chemotactic protein-1 production : ISS:UniProtKB
  • negative regulation of platelet-derived growth factor receptor signaling pathway : ISS:UniProtKB
  • negative regulation of protein import into nucleus : ISS:UniProtKB
  • negative regulation of smooth muscle cell proliferation : ISS:UniProtKB
  • negative regulation of smooth muscle cell-matrix adhesion : ISS:UniProtKB
  • negative regulation of T cell migration : ISS:UniProtKB
  • peripheral nervous system axon regeneration : ISS:UniProtKB
  • response to axon injury : ISS:UniProtKB
  • response to drug : ISS:UniProtKB
  • response to reactive oxygen species : IMP:UniProtKB
  • tissue regeneration : ISS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.