Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P50516

V-type proton ATPase catalytic subunit A (P50516)

Uniprot ID P50516
Protein Name V-type proton ATPase catalytic subunit A
Gene Name Atp6v1a
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.578
Function Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • proton-transporting ATPase activity, rotational mechanism : IBA:GO_Central
GO - Biological process
  • ATP hydrolysis coupled proton transport : IEA:InterPro
  • ATP metabolic process : IEA:InterPro
  • cellular iron ion homeostasis : ISS:UniProtKB
  • cellular response to increased oxygen levels : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.