Serpin B9 (P50453)

Uniprot ID P50453
Protein Name Serpin B9
Gene Name SERPINB9
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.62
Function Granzyme B inhibitor.
GO - Molecular function
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process : IDA:UniProtKB
  • protease binding : IPI:UniProtKB
  • serine-type endopeptidase inhibitor activity : IDA:UniProtKB
GO - Biological process
  • cellular response to estrogen stimulus : IEP:UniProtKB
  • immune response : IDA:UniProtKB
  • mast cell mediated immunity : IEP:UniProtKB
  • negative regulation by symbiont of host apoptotic process : IMP:UniProtKB
  • negative regulation of apoptotic process : IMP:UniProtKB
  • negative regulation of endopeptidase activity : IMP:UniProtKB
  • positive regulation of gene expression : IMP:UniProtKB
  • protection from natural killer cell mediated cytotoxicity : IMP:UniProtKB
  • response to bacterium : IDA:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.