C-C motif chemokine 5 (P50231)

Uniprot ID	P50231
Protein Name	C-C motif chemokine 5
Gene Name	Ccl5
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. .
GO - Molecular function	CCR chemokine receptor binding : IBA:GO_Central CCR1 chemokine receptor binding : ISO:RGD CCR5 chemokine receptor binding : ISO:RGD chemoattractant activity : ISO:RGD chemokine activity : IDA:RGD chemokine receptor antagonist activity : ISO:RGD chemokine receptor binding : ISO:RGD heparin binding : IDA:RGD identical protein binding : ISO:RGD phosphatidylinositol phospholipase C activity : ISO:RGD phospholipase activator activity : ISO:RGD protein homodimerization activity : ISO:RGD protein kinase activity : ISO:RGD protein self-association : ISO:RGD receptor signaling protein tyrosine kinase activator activity : ISO:RGD
GO - Biological process	activation of phospholipase D activity : ISO:RGD aging : IEP:RGD calcium ion transport : ISO:RGD cell-cell signaling : ISO:RGD cellular calcium ion homeostasis : ISO:RGD cellular response to alkyl hydroperoxide : IEP:RGD cellular response to amino acid stimulus : IEP:RGD cellular response to cytokine stimulus : IEP:RGD cellular response to ethanol : IEP:RGD cellular response to fibroblast growth factor stimulus : ISO:RGD cellular response to high density lipoprotein particle stimulus : IEP:RGD cellular response to interferon-gamma : ISO:RGD cellular response to interleukin-1 : ISO:RGD cellular response to lipid : IEP:RGD cellular response to lipopolysaccharide : IEP:RGD cellular response to morphine : IEP:RGD cellular response to organic cyclic compound : ISO:RGD cellular response to transforming growth factor beta stimulus : IEP:RGD cellular response to tumor necrosis factor : IEP:RGD cellular response to vitamin K : IEP:RGD chemokine-mediated signaling pathway : ISS:UniProtKB chronic inflammatory response : IEP:RGD dibenzo-p-dioxin metabolic process : IEP:RGD eosinophil chemotaxis : ISO:RGD exocytosis : ISO:RGD G protein-coupled receptor signaling pathway : ISS:UniProtKB inflammatory response : IEP:RGD leukocyte cell-cell adhesion : ISO:RGD lipopolysaccharide-mediated signaling pathway : ISO:RGD lymphocyte chemotaxis : IDA:RGD MAPK cascade : ISO:RGD monocyte chemotaxis : IBA:GO_Central negative regulation by host of viral transcription : ISO:RGD negative regulation of cell death : IMP:RGD negative regulation of G protein-coupled receptor signaling pathway : ISO:RGD negative regulation of macrophage apoptotic process : ISO:RGD negative regulation of neuron death : IMP:RGD negative regulation of T cell apoptotic process : ISO:RGD negative regulation of viral genome replication : ISO:RGD neutrophil activation : ISO:RGD neutrophil chemotaxis : IBA:GO_Central positive regulation of angiogenesis : IMP:RGD positive regulation of calcium ion transport : ISO:RGD positive regulation of cell adhesion : ISO:RGD positive regulation of cell migration : ISO:RGD positive regulation of cell-cell adhesion mediated by integrin : ISO:RGD positive regulation of cellular biosynthetic process : ISO:RGD positive regulation of epithelial cell proliferation : ISO:RGD positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central positive regulation of fever generation : IDA:RGD positive regulation of gene expression : IDA:RGD positive regulation of GTPase activity : IBA:GO_Central positive regulation of homotypic cell-cell adhesion : ISO:RGD positive regulation of macrophage chemotaxis : ISO:RGD positive regulation of mast cell chemotaxis : IDA:RGD positive regulation of monocyte chemotaxis : ISO:RGD positive regulation of natural killer cell chemotaxis : ISO:RGD positive regulation of neuron differentiation : IMP:RGD positive regulation of osteoclast differentiation : IDA:RGD positive regulation of phosphatidylinositol 3-kinase signaling : IDA:BHF-UCL positive regulation of phosphorylation : ISO:RGD positive regulation of smooth muscle cell migration : ISO:RGD positive regulation of smooth muscle cell proliferation : ISO:RGD positive regulation of T cell apoptotic process : ISO:RGD positive regulation of T cell chemotaxis : IDA:BHF-UCL positive regulation of T cell migration : ISO:RGD positive regulation of T cell proliferation : ISO:RGD positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD protein kinase B signaling : ISO:RGD pseudopodium assembly : IDA:BHF-UCL regulation of insulin secretion : ISS:UniProtKB regulation of neuron death : ISS:UniProtKB regulation of T cell activation : ISO:RGD response to activity : IEP:RGD response to bacterium : IEP:RGD response to cholesterol : IEP:RGD response to cytokine : IEP:RGD response to drug : IEP:RGD response to estrogen : IEP:RGD response to glucocorticoid : IEP:RGD response to insulin : IEP:RGD response to interferon-gamma : IDA:BHF-UCL response to lipopolysaccharide : IEP:RGD response to nutrient levels : IEP:RGD response to organic cyclic compound : IEP:RGD response to salt stress : IEP:RGD response to toxic substance : ISO:RGD response to tumor necrosis factor : ISO:RGD response to virus : IEP:RGD T-helper 1 cell diapedesis : IDA:BHF-UCL

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}