C-C motif chemokine 3 (P50229)

Uniprot ID	P50229
Protein Name	C-C motif chemokine 3
Gene Name	Ccl3
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
GO - Molecular function	calcium-dependent protein kinase C activity : ISS:UniProtKB CCR chemokine receptor binding : IBA:GO_Central CCR1 chemokine receptor binding : ISO:RGD CCR5 chemokine receptor binding : ISO:RGD chemoattractant activity : ISS:UniProtKB chemokine activity : IDA:RGD heparin binding : IEA:UniProtKB-KW identical protein binding : ISO:RGD kinase activity : ISS:UniProtKB phospholipase activator activity : ISS:UniProtKB protein kinase activity : ISS:UniProtKB
GO - Biological process	astrocyte cell migration : ISS:UniProtKB calcium ion transport : ISS:UniProtKB calcium-mediated signaling : ISS:UniProtKB cell activation : ISS:UniProtKB cell-cell signaling : ISS:UniProtKB cellular calcium ion homeostasis : ISS:UniProtKB cellular response to interferon-gamma : ISO:RGD cellular response to interleukin-1 : ISO:RGD cellular response to organic cyclic compound : ISS:UniProtKB cellular response to tumor necrosis factor : ISO:RGD chemokine-mediated signaling pathway : IBA:GO_Central chemotaxis : ISS:UniProtKB cytoskeleton organization : ISS:UniProtKB eosinophil chemotaxis : ISS:UniProtKB eosinophil degranulation : ISS:UniProtKB exocytosis : ISS:UniProtKB G protein-coupled receptor signaling pathway : IBA:GO_Central granulocyte chemotaxis : ISS:UniProtKB inflammatory response : IEP:RGD leukocyte chemotaxis : IDA:RGD lipopolysaccharide-mediated signaling pathway : ISS:UniProtKB lymphocyte chemotaxis : ISS:UniProtKB macrophage chemotaxis : ISS:UniProtKB MAPK cascade : ISS:UniProtKB monocyte chemotaxis : ISS:UniProtKB negative regulation by host of viral transcription : ISS:UniProtKB negative regulation of bone mineralization : ISO:RGD negative regulation of gene expression : ISS:UniProtKB negative regulation of osteoclast differentiation : ISS:UniProtKB neutrophil chemotaxis : IDA:RGD osteoblast differentiation : ISS:UniProtKB positive regulation of calcium ion transport : ISS:UniProtKB positive regulation of calcium-mediated signaling : ISS:UniProtKB positive regulation of cell migration : ISS:UniProtKB positive regulation of cytosolic calcium ion concentration : IDA:RGD positive regulation of ERK1 and ERK2 cascade : ISS:UniProtKB positive regulation of gene expression : ISS:UniProtKB positive regulation of GTPase activity : IBA:GO_Central positive regulation of inflammatory response : ISS:UniProtKB positive regulation of interleukin-1 beta secretion : ISS:UniProtKB positive regulation of natural killer cell chemotaxis : ISS:UniProtKB positive regulation of neuron apoptotic process : ISS:UniProtKB positive regulation of osteoclast differentiation : IDA:RGD positive regulation of protein kinase B signaling : ISO:RGD positive regulation of transcription by RNA polymerase II : ISO:RGD positive regulation of tumor necrosis factor production : ISS:UniProtKB protein kinase B signaling : ISS:UniProtKB protein phosphorylation : ISS:UniProtKB regulation of behavior : ISS:UniProtKB regulation of cell shape : ISS:UniProtKB regulation of sensory perception of pain : ISS:UniProtKB release of sequestered calcium ion into cytosol by sarcoplasmic reticulum : ISS:UniProtKB response to cholesterol : ISS:UniProtKB response to drug : IEP:RGD response to toxic substance : ISS:UniProtKB signaling : ISS:UniProtKB T cell chemotaxis : ISS:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}