Pentraxin-related protein PTX3 (P48759)

Uniprot ID P48759
Protein Name Pentraxin-related protein PTX3
Gene Name Ptx3
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.587
Function Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. .
GO - Molecular function
  • (1->3)-beta-D-glucan binding : IMP:MGI
  • complement component C1q binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • virion binding : ISO:MGI
GO - Biological process
  • innate immune response : ISO:MGI
  • negative regulation by host of viral exo-alpha-sialidase activity : ISO:MGI
  • negative regulation by host of viral glycoprotein metabolic process : ISO:MGI
  • negative regulation of exo-alpha-sialidase activity : ISO:MGI
  • negative regulation of glycoprotein metabolic process : ISO:MGI
  • negative regulation of viral entry into host cell : ISO:MGI
  • opsonization : IMP:MGI
  • positive regulation of nitric oxide biosynthetic process : IMP:MGI
  • positive regulation of phagocytosis : IMP:MGI
  • response to yeast : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.