Granulocyte-macrophage colony-stimulating factor (P48750)

Uniprot ID P48750
Protein Name Granulocyte-macrophage colony-stimulating factor
Gene Name Csf2
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. .
GO - Molecular function
  • cytokine activity : IDA:RGD
  • granulocyte macrophage colony-stimulating factor receptor binding : IEA:InterPro
  • growth factor activity : IEA:UniProtKB-KW
GO - Biological process
  • cellular response to granulocyte macrophage colony-stimulating factor stimulus : ISO:RGD
  • cellular response to lipopolysaccharide : IEP:RGD
  • dendritic cell differentiation : IDA:RGD
  • embryonic placenta development : ISO:RGD
  • epithelial cell proliferation : TAS:RGD
  • epithelial fluid transport : IDA:RGD
  • histamine secretion : IDA:RGD
  • immune response : IEA:InterPro
  • leukocyte differentiation : IBA:GO_Central
  • macrophage activation : IMP:RGD
  • macrophage differentiation : ISO:RGD
  • monocyte differentiation : ISO:RGD
  • myeloid dendritic cell differentiation : ISO:RGD
  • negative regulation of cytolysis : ISO:RGD
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
  • negative regulation of transcription, DNA-templated : ISO:RGD
  • neutrophil differentiation : ISO:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of gene expression : ISO:RGD
  • positive regulation of interleukin-23 production : ISO:RGD
  • positive regulation of macrophage derived foam cell differentiation : ISO:RGD
  • positive regulation of macrophage differentiation : TAS:RGD
  • positive regulation of podosome assembly : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • regulation of cell population proliferation : ISO:RGD
  • regulation of circadian sleep/wake cycle, sleep : IMP:RGD
  • regulation of gene expression : ISO:RGD
  • response to fluid shear stress : IEP:RGD
  • response to silicon dioxide : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.