Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
Function |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. |
GO - Molecular function |
- metalloendopeptidase inhibitor activity : IBA:GO_Central
- protease binding : IBA:GO_Central
- zinc ion binding : ISS:UniProtKB
|
GO - Biological process |
- aging : IEP:RGD
- cellular response to organic substance : ISO:RGD
- central nervous system development : IEP:RGD
- negative regulation of endopeptidase activity : IBA:GO_Central
- negative regulation of ERK1 and ERK2 cascade : ISO:RGD
- negative regulation of membrane protein ectodomain proteolysis : ISO:RGD
- negative regulation of metalloendopeptidase activity : ISO:RGD
- negative regulation of proteolysis : IMP:RGD
- positive regulation of TRAIL-activated apoptotic signaling pathway : ISO:RGD
- response to amino acid : IEP:RGD
- response to cytokine : IBA:GO_Central
- response to estrogen : IEP:RGD
- response to folic acid : IEP:RGD
- response to hormone : IEP:RGD
- response to mechanical stimulus : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- response to organic substance : IEP:RGD
- tissue regeneration : IEP:RGD
|