F-actin-capping protein subunit beta (P47757)

Uniprot ID P47757
Protein Name F-actin-capping protein subunit beta
Gene Name Capzb
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.645
Function F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). .
GO - Molecular function
  • actin binding : ISO:MGI
  • beta-tubulin binding : IPI:MGI
  • cadherin binding : ISO:MGI
GO - Biological process
  • actin cytoskeleton organization : IEA:InterPro
  • barbed-end actin filament capping : IDA:MGI
  • cell morphogenesis : IBA:GO_Central
  • cell projection organization : IMP:MGI
  • cytoskeleton organization : ISS:UniProtKB
  • lamellipodium assembly : IMP:MGI
  • muscle fiber development : IMP:MGI
  • negative regulation of filopodium assembly : IBA:GO_Central
  • negative regulation of microtubule polymerization : IDA:MGI
  • neuron projection development : IMP:MGI
  • regulation of cell morphogenesis : ISS:UniProtKB
  • regulation of lamellipodium assembly : IBA:GO_Central
  • regulation of protein kinase C signaling : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.