| Signal peptide(a) |
N |
Secretome P(b) |
0.645 |
| Function |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). . |
| GO - Molecular function |
- actin binding : ISO:MGI
- beta-tubulin binding : IPI:MGI
- cadherin binding : ISO:MGI
|
| GO - Biological process |
- actin cytoskeleton organization : IEA:InterPro
- barbed-end actin filament capping : IDA:MGI
- cell morphogenesis : IBA:GO_Central
- cell projection organization : IMP:MGI
- cytoskeleton organization : ISS:UniProtKB
- lamellipodium assembly : IMP:MGI
- muscle fiber development : IMP:MGI
- negative regulation of filopodium assembly : IBA:GO_Central
- negative regulation of microtubule polymerization : IDA:MGI
- neuron projection development : IMP:MGI
- regulation of cell morphogenesis : ISS:UniProtKB
- regulation of lamellipodium assembly : IBA:GO_Central
- regulation of protein kinase C signaling : IMP:MGI
|