Aldose reductase (P45376)

Uniprot ID P45376
Protein Name Aldose reductase
Gene Name Akr1b1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.636
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
GO - Molecular function
  • alditol : IDA:MGI
  • glyceraldehyde oxidoreductase activity : ISO:MGI
GO - Biological process
  • cellular hyperosmotic salinity response : ISO:MGI
  • cellular response to hydrogen peroxide : ISO:MGI
  • cellular response to methylglyoxal : ISO:MGI
  • cellular response to peptide : IEA:Ensembl
  • daunorubicin metabolic process : ISO:MGI
  • doxorubicin metabolic process : ISO:MGI
  • inner medullary collecting duct development : ISO:MGI
  • maternal process involved in female pregnancy : IEA:Ensembl
  • monosaccharide metabolic process : ISO:MGI
  • naphthalene metabolic process : ISO:MGI
  • negative regulation of apoptotic process : IMP:MGI
  • norepinephrine metabolic process : ISO:MGI
  • oxidation-reduction process : ISO:MGI
  • positive regulation of JAK-STAT cascade : ISO:MGI
  • positive regulation of smooth muscle cell proliferation : ISO:MGI
  • regulation of urine volume : IDA:MGI
  • renal system development : IMP:MGI
  • renal water homeostasis : IMP:MGI
  • response to organic substance : ISO:MGI
  • response to thyroid hormone : IEA:Ensembl
  • response to water deprivation : ISO:MGI
  • sorbitol biosynthetic process : ISO:MGI
  • stress-activated protein kinase signaling cascade : ISO:MGI
  • tissue homeostasis : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.