Signal transducer and activator of transcription 1 (P42225)

Uniprot ID P42225
Protein Name Signal transducer and activator of transcription 1
Gene Name Stat1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. .
GO - Molecular function
  • CCR5 chemokine receptor binding : ISO:MGI
  • DNA binding : ISO:MGI
  • DNA-binding transcription activator activity, RNA polymerase II-specific : IBA:GO_Central
  • DNA-binding transcription factor activity : IMP:MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific : ISO:MGI
  • double-stranded DNA binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • histone acetyltransferase binding : ISO:MGI
  • histone binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • nuclear hormone receptor binding : ISO:MGI
  • promoter-specific chromatin binding : ISO:MGI
  • protein homodimerization activity : ISS:UniProtKB
  • protein phosphatase 2A binding : ISO:MGI
  • repressing transcription factor binding : ISO:MGI
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding : ISO:MGI
  • RNA polymerase II core promoter sequence-specific DNA binding : ISS:UniProtKB
  • sequence-specific DNA binding : ISO:MGI
  • tumor necrosis factor receptor binding : ISO:MGI
  • ubiquitin-like protein ligase binding : ISO:MGI
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : IMP:UniProtKB
  • blood circulation : ISS:UniProtKB
  • cellular response to cytokine stimulus : ISO:MGI
  • cellular response to insulin stimulus : ISO:MGI
  • cellular response to interferon-beta : ISO:MGI
  • cellular response to interferon-gamma : ISO:MGI
  • cellular response to lipopolysaccharide : IMP:MGI
  • cellular response to organic cyclic compound : ISO:MGI
  • cytokine-mediated signaling pathway : IDA:MGI
  • defense response : IBA:GO_Central
  • defense response to virus : ISS:UniProtKB
  • interferon-gamma-mediated signaling pathway : IMP:UniProtKB
  • lipopolysaccharide-mediated signaling pathway : IDA:MGI
  • macrophage derived foam cell differentiation : ISS:UniProtKB
  • metanephric mesenchymal cell differentiation : ISS:UniProtKB
  • metanephric mesenchymal cell proliferation involved in metanephros development : ISS:UniProtKB
  • negative regulation by virus of viral protein levels in host cell : ISO:MGI
  • negative regulation of angiogenesis : ISO:MGI
  • negative regulation of endothelial cell proliferation : ISO:MGI
  • negative regulation of I-kappaB kinase/NF-kappaB signaling : ISO:MGI
  • negative regulation of macrophage fusion : IMP:MGI
  • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis : ISS:UniProtKB
  • negative regulation of metanephric nephron tubule epithelial cell differentiation : ISS:UniProtKB
  • negative regulation of transcription by RNA polymerase II : ISS:UniProtKB
  • positive regulation of cell population proliferation : ISO:MGI
  • positive regulation of defense response to virus by host : ISO:MGI
  • positive regulation of erythrocyte differentiation : ISS:UniProtKB
  • positive regulation of interferon-alpha production : ISS:UniProtKB
  • positive regulation of mesenchymal cell proliferation : ISS:UniProtKB
  • positive regulation of nitric-oxide synthase biosynthetic process : ISO:MGI
  • positive regulation of smooth muscle cell proliferation : ISS:UniProtKB
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
  • positive regulation of transcription, DNA-templated : ISO:MGI
  • receptor signaling pathway via JAK-STAT : ISO:MGI
  • regulation of cell population proliferation : IBA:GO_Central
  • renal tubule development : ISS:UniProtKB
  • response to bacterium : IDA:MGI
  • response to cAMP : ISS:UniProtKB
  • response to cytokine : ISS:UniProtKB
  • response to drug : ISO:MGI
  • response to exogenous dsRNA : IDA:MGI
  • response to interferon-beta : ISO:MGI
  • response to lipopolysaccharide : IDA:MGI
  • response to mechanical stimulus : ISO:MGI
  • response to nutrient : ISO:MGI
  • response to peptide hormone : ISS:UniProtKB
  • response to type I interferon : IDA:UniProtKB
  • transcription, DNA-templated : IMP:MGI
  • tumor necrosis factor-mediated signaling pathway : ISO:MGI
  • type I interferon signaling pathway : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.