Septin-2 (P42208)

Uniprot ID P42208
Protein Name Septin-2
Gene Name Sept2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.463
Function Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • enzyme regulator activity : IDA:MGI
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : NAS:UniProtKB
  • identical protein binding : ISO:MGI
  • protein-containing complex scaffold activity : IDA:MGI
GO - Biological process
  • cilium assembly : IMP:UniProtKB
  • cytoskeleton-dependent cytokinesis : NAS:UniProtKB
  • neuron projection development : ISO:MGI
  • protein polymerization : TAS:MGI
  • regulation of L-glutamate import across plasma membrane : IDA:MGI
  • regulation of protein localization : IDA:MGI
  • smoothened signaling pathway : IMP:UniProtKB
  • spermatogenesis : IEA:UniProtKB-KW
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.