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P42203

Interleukin-13 (P42203)

Uniprot ID P42203
Protein Name Interleukin-13
Gene Name Il13
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. .
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
  • interleukin-13 receptor binding : IPI:RGD
GO - Biological process
  • cellular response to cytokine stimulus : ISO:RGD
  • cellular response to mechanical stimulus : IEP:RGD
  • immune response : IEA:InterPro
  • inflammatory response : ISO:RGD
  • microglial cell activation : IMP:RGD
  • negative regulation of complement-dependent cytotoxicity : ISO:RGD
  • negative regulation of endothelial cell apoptotic process : ISO:RGD
  • negative regulation of inflammatory response : IEA:Ensembl
  • negative regulation of NAD(P)H oxidase activity : IMP:RGD
  • negative regulation of neuron death : IMP:RGD
  • negative regulation of transforming growth factor beta production : IDA:RGD
  • positive regulation of B cell proliferation : IDA:RGD
  • positive regulation of cold-induced thermogenesis : ISS:YuBioLab
  • positive regulation of connective tissue growth factor production : IDA:RGD
  • positive regulation of gene expression : IDA:ARUK-UCL
  • positive regulation of immunoglobulin production : IDA:RGD
  • positive regulation of interleukin-10 secretion : IEA:Ensembl
  • positive regulation of ion transport : IDA:RGD
  • positive regulation of macrophage activation : ISO:RGD
  • positive regulation of mast cell degranulation : ISO:RGD
  • positive regulation of pancreatic stellate cell proliferation : IDA:RGD
  • positive regulation of protein secretion : IDA:RGD
  • positive regulation of release of sequestered calcium ion into cytosol : IDA:RGD
  • positive regulation of smooth muscle cell proliferation : IDA:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : IDA:RGD
  • regulation of proton transport : IDA:RGD
  • response to ethanol : IEP:RGD
  • response to lipopolysaccharide : IEP:RGD
  • response to mechanical stimulus : IEP:RGD
  • response to nicotine : IDA:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.