Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P40190

Interleukin-6 receptor subunit beta (P40190)

Uniprot ID P40190
Protein Name Interleukin-6 receptor subunit beta
Gene Name Il6st
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (9) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. .
GO - Molecular function
  • ciliary neurotrophic factor receptor activity : ISO:RGD
  • ciliary neurotrophic factor receptor binding : ISO:RGD
  • cytokine binding : IBA:GO_Central
  • cytokine receptor activity : IBA:GO_Central
  • growth factor binding : ISO:RGD
  • identical protein binding : ISO:RGD
GO - Biological process
  • ciliary neurotrophic factor-mediated signaling pathway : ISO:RGD
  • cytokine-mediated signaling pathway : ISO:RGD
  • glycogen metabolic process : ISO:RGD
  • interleukin-11-mediated signaling pathway : IEA:GOC
  • interleukin-27-mediated signaling pathway : ISO:RGD
  • interleukin-6-mediated signaling pathway : IMP:RGD
  • leukemia inhibitory factor signaling pathway : ISO:RGD
  • negative regulation of cytosolic calcium ion concentration : IMP:RGD
  • negative regulation of interleukin-6-mediated signaling pathway : ISO:RGD
  • oncostatin-M-mediated signaling pathway : ISO:RGD
  • positive regulation of astrocyte differentiation : ISO:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of osteoblast differentiation : ISO:RGD
  • positive regulation of smooth muscle cell migration : IMP:RGD
  • positive regulation of T cell proliferation : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • regulation of hormone secretion : TAS:RGD
  • regulation of Notch signaling pathway : ISO:RGD
  • response to cytokine : ISO:RGD
  • response to nutrient : IEP:RGD
  • signal transduction : ISO:RGD
  • triglyceride mobilization : IMP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.