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P40142

Transketolase (P40142)

Uniprot ID P40142
Protein Name Transketolase
Gene Name Tkt
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (4) Interactions
Signal peptide(a) N Secretome P(b) 0.589
Function Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. .
GO - Molecular function
  • carbohydrate binding : ISO:MGI
  • cofactor binding : ISO:MGI
  • magnesium ion binding : ISO:MGI
  • monosaccharide binding : ISO:MGI
  • protein homodimerization activity : ISO:MGI
  • thiamine pyrophosphate binding : ISO:MGI
  • transketolase activity : IDA:MGI
GO - Biological process
  • glyceraldehyde-3-phosphate biosynthetic process : ISO:MGI
  • pentose-phosphate shunt : ISO:MGI
  • pentose-phosphate shunt, non-oxidative branch : ISO:MGI
  • regulation of growth : IMP:MGI
  • ribose phosphate biosynthetic process : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.