| Signal peptide(a) |
Y |
Secretome P(b) |
0.12 |
| Function |
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. .Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. {ECO:0000250|UniProtKB:P39060}.Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168). Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087). Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity). {ECO:0000250|UniProtKB:P39060, ECO:0000269|PubMed:11158588, ECO:0000269|PubMed:9008168}. |
| GO - Molecular function |
- metal ion binding : IEA:UniProtKB-KW
- structural molecule activity : IEA:InterPro
|
| GO - Biological process |
- angiogenesis : IDA:MGI
- cell adhesion : IEA:UniProtKB-KW
- endothelial cell morphogenesis : IDA:MGI
- extracellular matrix organization : IMP:MGI
- positive regulation of cell migration : IDA:MGI
- positive regulation of cell proliferation : IDA:MGI
- positive regulation of endothelial cell apoptotic process : IDA:MGI
|