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P38647

Stress-70 protein, mitochondrial (P38647)

Uniprot ID P38647
Protein Name Stress-70 protein, mitochondrial
Gene Name Hspa9
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.296
Function Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis (PubMed:26702583). Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823). May play a role in the control of cell proliferation and cellular aging (PubMed:8454632). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • chaperone binding : ISO:MGI
  • enzyme binding : IPI:UniProtKB
  • fibroblast growth factor binding : ISO:MGI
  • heat shock protein binding : ISO:MGI
  • ubiquitin protein ligase binding : ISO:MGI
  • unfolded protein binding : IEA:InterPro
GO - Biological process
  • erythrocyte differentiation : ISS:UniProtKB
  • iron-sulfur cluster assembly : IMP:UniProtKB
  • negative regulation of cell death : ISO:MGI
  • negative regulation of erythrocyte differentiation : ISS:UniProtKB
  • negative regulation of hematopoietic stem cell differentiation : IMP:UniProtKB
  • negative regulation of hemopoiesis : IMP:UniProtKB
  • protein autophosphorylation : ISO:MGI
  • protein export from nucleus : IDA:MGI
  • protein folding : IEA:InterPro
  • regulation of erythrocyte differentiation : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.