Adenine phosphoribosyltransferase (P36972)

Uniprot ID P36972
Protein Name Adenine phosphoribosyltransferase
Gene Name Aprt
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
GO - Molecular function
  • adenine binding : ISO:RGD
  • adenine phosphoribosyltransferase activity : ISO:RGD
  • AMP binding : IDA:RGD
GO - Biological process
  • adenine metabolic process : ISO:RGD
  • adenine salvage : ISO:RGD
  • AMP salvage : IBA:GO_Central
  • cellular response to insulin stimulus : IEP:RGD
  • grooming behavior : ISO:RGD
  • lactation : IDA:RGD
  • purine ribonucleoside salvage : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.