| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . |
| GO - Molecular function |
- amyloid-beta binding : ISO:RGD
- calcium ion binding : IEA:InterPro
- identical protein binding : ISO:RGD
- low-density lipoprotein particle binding : ISO:RGD
- low-density lipoprotein particle receptor activity : IDA:RGD
- protease binding : ISO:RGD
- very-low-density lipoprotein particle receptor activity : ISO:RGD
|
| GO - Biological process |
- aging : IEP:RGD
- amyloid-beta clearance : ISO:RGD
- amyloid-beta clearance by cellular catabolic process : ISO:RGD
- artery morphogenesis : ISO:RGD
- cellular response to fatty acid : ISO:RGD
- cellular response to low-density lipoprotein particle stimulus : ISO:RGD
- cholesterol homeostasis : ISO:RGD
- cholesterol import : ISO:RGD
- cholesterol metabolic process : ISO:RGD
- cholesterol transport : ISO:RGD
- endocytosis : IMP:RGD
- high-density lipoprotein particle clearance : ISO:RGD
- intestinal cholesterol absorption : ISO:RGD
- lipid metabolic process : ISO:RGD
- lipoprotein catabolic process : ISO:RGD
- lipoprotein metabolic process : ISO:RGD
- long-term memory : ISO:RGD
- low-density lipoprotein particle clearance : ISO:RGD
- negative regulation of amyloid fibril formation : ISO:RGD
- negative regulation of astrocyte activation : ISO:RGD
- negative regulation of gene expression : ISO:RGD
- negative regulation of microglial cell activation : ISO:RGD
- negative regulation of protein metabolic process : ISO:RGD
- phagocytosis : ISO:RGD
- phospholipid transport : ISO:RGD
- plasma lipoprotein particle clearance : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of inflammatory response : ISO:RGD
- positive regulation of lysosomal protein catabolic process : ISO:RGD
- positive regulation of triglyceride biosynthetic process : ISO:RGD
- positive regulation of triglyceride catabolic process : IMP:RGD
- receptor-mediated endocytosis : ISO:RGD
- receptor-mediated endocytosis involved in cholesterol transport : ISO:RGD
- regulation of cholesterol metabolic process : ISO:RGD
- regulation of phosphatidylcholine catabolic process : ISO:RGD
- regulation of protein metabolic process : ISO:RGD
- response to caloric restriction : ISO:RGD
- response to estradiol : IEP:RGD
- response to estrogen : IEP:RGD
- response to glucagon : IEP:RGD
- response to hormone : IEP:RGD
- response to hypoxia : IEP:RGD
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