| Signal peptide(a) |
Y |
Secretome P(b) |
0.469 |
| Function |
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . |
| GO - Molecular function |
- amyloid-beta binding : IPI:ARUK-UCL
- calcium ion binding : IEA:InterPro
- identical protein binding : ISO:MGI
- low-density lipoprotein particle binding : IDA:MGI
- low-density lipoprotein particle receptor activity : IDA:MGI
- protease binding : ISO:MGI
- very-low-density lipoprotein particle receptor activity : IDA:MGI
|
| GO - Biological process |
- amyloid-beta clearance : IDA:ARUK-UCL
- cellular response to fatty acid : IGI:BHF-UCL
- cellular response to low-density lipoprotein particle stimulus : ISO:MGI
- cholesterol homeostasis : IMP:MGI
- cholesterol import : IMP:BHF-UCL
- cholesterol metabolic process : IMP:MGI
- cholesterol transport : IMP:MGI
- endocytosis : ISO:MGI
- intestinal cholesterol absorption : ISO:MGI
- lipid metabolic process : IGI:MGI
- lipoprotein catabolic process : IDA:MGI
- lipoprotein metabolic process : IGI:MGI
- long-term memory : IGI:ARUK-UCL
- low-density lipoprotein particle clearance : IDA:MGI
- negative regulation of amyloid fibril formation : IGI:ARUK-UCL
- negative regulation of astrocyte activation : IGI:ARUK-UCL
- negative regulation of gene expression : IMP:BHF-UCL
- negative regulation of microglial cell activation : IGI:ARUK-UCL
- negative regulation of protein metabolic process : IDA:ARUK-UCL
- phospholipid transport : IMP:BHF-UCL
- positive regulation of amyloid-beta clearance : IDA:ARUK-UCL
- positive regulation of endocytosis : IDA:ARUK-UCL
- positive regulation of gene expression : IMP:BHF-UCL
- positive regulation of inflammatory response : IGI:BHF-UCL
- positive regulation of lipoprotein particle clearance : IDA:ARUK-UCL
- positive regulation of lysosomal protein catabolic process : IDA:ARUK-UCL
- positive regulation of triglyceride biosynthetic process : IMP:BHF-UCL
- positive regulation of triglyceride catabolic process : ISO:MGI
- receptor-mediated endocytosis : IDA:ARUK-UCL
- receptor-mediated endocytosis involved in cholesterol transport : ISO:MGI
- regulation of cholesterol metabolic process : IGI:ARUK-UCL
- regulation of phosphatidylcholine catabolic process : IMP:BHF-UCL
- regulation of protein metabolic process : IGI:ARUK-UCL
- response to caloric restriction : IGI:ARUK-UCL
|