Insulin-degrading enzyme (P35559)

Uniprot ID P35559
Protein Name Insulin-degrading enzyme
Gene Name Ide
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:1836994, PubMed:1445854, PubMed:10684867, PubMed:12941771, PubMed:14527953, PubMed:22049080). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:10684867). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I. .
GO - Molecular function
  • amyloid-beta binding : IPI:RGD
  • ATP binding : IMP:RGD
  • ATPase activity : IDA:RGD
  • beta-endorphin binding : IMP:RGD
  • endopeptidase activity : ISO:RGD
  • identical protein binding : IPI:RGD
  • insulin binding : IMP:RGD
  • metalloendopeptidase activity : IDA:RGD
  • peptidase activity : TAS:RGD
  • peptide binding : ISO:RGD
  • peptide hormone binding : IPI:RGD
  • protein homodimerization activity : ISO:RGD
  • protein-containing complex binding : IDA:RGD
  • ubiquitin-dependent protein binding : ISO:RGD
  • zinc ion binding : IMP:RGD
GO - Biological process
  • amyloid-beta clearance : IMP:ARUK-UCL
  • amyloid-beta clearance by cellular catabolic process : IMP:ARUK-UCL
  • amyloid-beta metabolic process : IMP:RGD
  • antigen processing and presentation of endogenous peptide antigen via MHC class I : ISS:UniProtKB
  • bradykinin catabolic process : ISS:UniProtKB
  • cellular protein catabolic process : IDA:RGD
  • determination of adult lifespan : ISO:RGD
  • hormone catabolic process : IDA:RGD
  • insulin catabolic process : ISS:UniProtKB
  • insulin metabolic process : ISO:RGD
  • negative regulation of proteolysis : IDA:RGD
  • peptide catabolic process : ISS:UniProtKB
  • positive regulation of protein binding : IEA:Ensembl
  • positive regulation of protein oligomerization : ISO:RGD
  • protein catabolic process : ISO:RGD
  • protein homooligomerization : ISO:RGD
  • proteolysis : ISO:RGD
  • proteolysis involved in cellular protein catabolic process : IMP:RGD
  • regulation of aerobic respiration : ISO:RGD
  • ubiquitin recycling : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.