14-3-3 protein zeta/delta (P35215)

Uniprot ID P35215
Protein Name 14-3-3 protein zeta/delta
Gene Name Ywhaz
Species Mus musculus (Mouse)
Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
GO - Molecular function
  • cadherin binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • ion channel binding : ISO:MGI
  • protein domain specific binding : IDA:UniProtKB
  • protein kinase binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • transcription factor binding : ISO:MGI
  • ubiquitin protein ligase binding : ISO:MGI
  • protein domain specific binding : ISS:UniProtKB
  • protein-containing complex binding : IPI:RGD
GO - Biological process
  • establishment of Golgi localization : ISO:MGI
  • Golgi reassembly : ISO:MGI
  • histamine secretion by mast cell : ISO:MGI
  • protein targeting : IDA:MGI
  • protein targeting to mitochondrion : ISO:MGI
  • regulation of cell death : IGI:MGI
  • response to drug : ISO:MGI
  • histamine secretion by mast cell : IMP:RGD
  • protein targeting to mitochondrion : IDA:RGD
  • response to drug : IDA:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.