| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Cell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions (By similarity). Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. . |
| GO - Molecular function |
- collagen V binding : IPI:RGD
- copper ion binding : ISS:UniProtKB
- fibroblast growth factor binding : ISS:UniProtKB
- laminin binding : ISS:UniProtKB
|
| GO - Biological process |
- cell migration : IBA:GO_Central
- heparan sulfate proteoglycan catabolic process : ISS:UniProtKB
- myelin assembly : IDA:UniProtKB
- negative regulation of fibroblast growth factor receptor signaling pathway : ISS:UniProtKB
- positive regulation of skeletal muscle cell differentiation : ISS:UniProtKB
- regulation of protein localization to membrane : IBA:GO_Central
- Schwann cell differentiation : IDA:UniProtKB
|