Cytokine response-modifying protein B (P34015)

Uniprot ID P34015
Protein Name Cytokine response-modifying protein B
Gene Name CRMB
Species Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Signal peptide(a) N Secretome P(b)
Function Inhibits host immune defense by binding to host TNF and various chemokines (PubMed:16581912, PubMed:17070121). Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines) (PubMed:16581912). .
GO - Molecular function
GO - Biological process
  • evasion or tolerance by virus of host immune response : IEA:UniProtKB-KW
  • suppression by virus of host chemokine activity : IEA:UniProtKB-KW
  • evasion or tolerance by virus of host immune response : IEA:UniProtKB-KW
  • suppression by virus of host chemokine activity : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.