| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095). . |
| GO - Molecular function |
- chromatin binding : IDA:MGI
- DNA binding : IDA:MGI
- protein N-terminus binding : IPI:MGI
- protein-containing complex binding : ISO:MGI
- repressing transcription factor binding : ISO:MGI
- RNA polymerase II proximal promoter sequence-specific DNA binding : IDA:MGI
- RNA polymerase II repressing transcription factor binding : ISO:MGI
- sequence-specific DNA binding : IDA:MGI
- transcription factor binding : IPI:MGI
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding : ISO:MGI
- transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding : IDA:BHF-UCL
|
| GO - Biological process |
- angiogenesis : IMP:MGI
- arterial endothelial cell fate commitment : IMP:BHF-UCL
- artery morphogenesis : IMP:MGI
- atrioventricular canal development : IMP:BHF-UCL
- auditory receptor cell fate commitment : IMP:MGI
- B cell differentiation : IMP:MGI
- blood vessel endothelial cell fate specification : IGI:BHF-UCL
- blood vessel lumenization : IMP:BHF-UCL
- blood vessel remodeling : IMP:BHF-UCL
- cardiac left ventricle morphogenesis : IMP:BHF-UCL
- cell fate commitment : IMP:MGI
- Clara cell differentiation : IMP:MGI
- defense response to bacterium : IMP:MGI
- determination of heart left/right asymmetry : TAS:BHF-UCL
- dorsal aorta morphogenesis : IMP:BHF-UCL
- endocardium development : IMP:BHF-UCL
- endocardium morphogenesis : IMP:BHF-UCL
- epidermal cell fate specification : IMP:MGI
- epithelial to mesenchymal transition : IMP:MGI
- epithelial to mesenchymal transition involved in endocardial cushion formation : IMP:BHF-UCL
- hair follicle maturation : IMP:MGI
- heart development : IMP:MGI
- heart looping : TAS:BHF-UCL
- hemopoiesis : IMP:MGI
- humoral immune response : IMP:MGI
- inflammatory response to antigenic stimulus : IMP:MGI
- interleukin-4 secretion : IMP:MGI
- keratinocyte differentiation : IMP:MGI
- labyrinthine layer blood vessel development : IMP:BHF-UCL
- myeloid dendritic cell differentiation : IMP:MGI
- negative regulation of cell differentiation : IMP:MGI
- negative regulation of cell proliferation : IMP:MGI
- negative regulation of neuron projection development : ISO:MGI
- negative regulation of ossification : IMP:BHF-UCL
- negative regulation of smooth muscle cell apoptotic process : ISO:MGI
- negative regulation of smooth muscle cell migration : ISO:MGI
- negative regulation of transcription by RNA polymerase II : IMP:BHF-UCL
- negative regulation of transcription, DNA-templated : IDA:MGI
- neuron differentiation : IMP:MGI
- Notch signaling pathway : IMP:MGI
- Notch signaling pathway involved in arterial endothelial cell fate commitment : IC:BHF-UCL
- outflow tract morphogenesis : IMP:BHF-UCL
- pituitary gland development : IMP:MGI
- positive regulation of BMP signaling pathway : IMP:BHF-UCL
- positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment : IMP:MGI
- positive regulation of cardiac muscle cell proliferation : IMP:BHF-UCL
- positive regulation of cell proliferation : IGI:MGI
- positive regulation of cell proliferation involved in heart morphogenesis : IMP:BHF-UCL
- positive regulation of ephrin receptor signaling pathway : IMP:BHF-UCL
- positive regulation of ERBB signaling pathway : IMP:BHF-UCL
- positive regulation of gene expression : IMP:BHF-UCL
- positive regulation of Notch signaling pathway involved in heart induction : TAS:BHF-UCL
- positive regulation of smooth muscle cell proliferation : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia : ISS:UniProtKB
- positive regulation of transcription of Notch receptor target : IGI:MGI
- positive regulation of transcription, DNA-templated : ISO:MGI
- regulation of cell adhesion involved in heart morphogenesis : IC:BHF-UCL
- regulation of cell proliferation : IGI:MGI
- regulation of gene expression : IMP:MGI
- regulation of timing of cell differentiation : IMP:MGI
- regulation of transcription by RNA polymerase II : IGI:MGI
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation : IMP:BHF-UCL
- sebaceous gland development : IMP:MGI
- secondary heart field specification : IMP:MGI
- somatic stem cell population maintenance : IMP:MGI
- somitogenesis : IMP:MGI
- ventricular trabecula myocardium morphogenesis : IMP:BHF-UCL
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