Vimentin (P31000)

Uniprot ID P31000
Protein Name Vimentin
Gene Name Vim
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b) 0.0
Function Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. .Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000250}.
GO - Molecular function
  • kinase binding : IPI:RGD
  • protein kinase binding : IPI:RGD
  • protein phosphatase 2A binding : IDA:RGD
  • structural constituent of cytoskeleton : ISS:UniProtKB
  • structural molecule activity : TAS:RGD
GO - Biological process
  • aging : IEP:RGD
  • cellular response to fibroblast growth factor stimulus : IEP:RGD
  • cellular response to lipopolysaccharide : ISS:UniProtKB
  • cellular response to muramyl dipeptide : ISS:UniProtKB
  • decidualization : IEP:RGD
  • fat cell differentiation : IEP:RGD
  • positive regulation of glial cell proliferation : IMP:RGD
  • regulation of axonogenesis : IDA:RGD
  • regulation of Schwann cell migration : IDA:RGD
  • response to estradiol : IEP:RGD
  • response to radiation : IEP:RGD
  • response to selenium ion : IEP:RGD
  • response to vitamin D : IEP:RGD
  • response to zinc ion : IEP:RGD
  • skeletal muscle tissue regeneration : IEP:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.